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Several factors can contribute to this more vulnerable environment: declining estrogen levels during menopause lower muscle mass during rapid weight loss reduced resistance training activity aggressive calorie restriction reduced protein intake lower mechanical loading through movement and exercise This does not mean GLP-1 medications directly cause osteoporosis

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The trade-off is that the analogue is a poor model of native IGF-I physiology precisely because it bypasses the buffering system that governs it

Rapid weight loss requires muscle building

Ramesh jokingly said, hehe