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Because retatrutide is administered as a once-weekly subcutaneous injection, its long pharmacokinetic half-life estimated at approximately six days in the Phase 2 trial data means that plasma concentrations remain relatively stable throughout the week
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This has potential to alleviate supply shortages currently plaguing the class, and may provide an opportunity for Lilly to bring a lower-cost option to market, though Lillys pricing strategy for orforglipron is unknown and likely to be dependent upon clinical results
In contrast, none of the GLP-1 analogs showed any significant suppressive effects on pro-inflammatory gene expression (Fig
Rowlands, D
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