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The problem surfaced in clinical trials run in 1992 by Mojsov and David Nathan, a physician and expert in type 2 diabetes at MGH, and those of Holst and Nauck (Molteni, Chen)

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This model provides a tool, different from laboratory experimentation, that can be used to experiment with one-carbon and glutathione metabolism

Concomitant antidiabetic medication use may also confound the observed neurological event associations

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