In the context of severe intestinal lesions such as the crypt loss observed in inflammatory bowel disease (IBD), LGR5 + intestinal stem cells (ISCs) vigorously proliferate and differentiate to replenish the cellular pool essential for restoring the epithelial barrier, thus promoting epithelial regeneration post-injury 1,2
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The thyroid gland contains iodine, this element and Se have a synergistic relationship for a healthy thyroid gland and therefore both these elements in proper amounts are needed
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References Haroche J, Cohen-Aubart F, Emile JF, et al
The syndrome has been diagnosed in children ranging from 1 to 20 years of age, though the majority of cases occur in children aged 1 to 14 years