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Reputable suppliers provide certificates of analysis (COA) showing purity, identity, and potency for each batch

In addition, berberine can aggravate the cytotoxicity induced by 6-OHDA in PC12 cells and aggravate of dopaminergic neuron death (Kwon et al., 2010)

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DahlinMHjelteLNilssonSAmarkP.Plasma phospholipid fatty acids are influenced by a ketogenic diet enriched with N-3 fatty acids in children with epilepsy

This suggests that either the side effects were manageable enough to tolerate, or that the visible results motivated continued use through uncomfortable periods