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This complex process means that conditions affecting the stomach or intestines can significantly impair B12 absorption, including pernicious anaemia, atrophic gastritis, previous gastric surgery, coeliac disease, Crohn's disease, and long-term use of certain medications (such as metformin, proton pump inhibitors, and H2 antagonists)

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H 2 -receptor antagonist examples include cimetidine, famotidine, nizatidine, and ranitidine

Looijenga LHJ, Hersmus R, de Leeuw, Bertie H, C G M, Stoop H, Cools M, Oosterhuis JW, Drop SLS, Wolffenbuttel KP (2010) Gonadal tumours and DSD

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Its also important to address your horses basic nutritional requirements