Dapagliflozin in patients with type 2 diabetes receiving high doses of insulin: efficacy and safety over 2 years

Abbreviations ALC: Acetyl L-Carnitine ART: Assisted reproductive technology BCB: Brilliant cresyl blue CoA: Coenzyme-A COC: Cumulus-oocyte complex CPT: Cartinitine palmitoyltransferase DHEA: Dehydroepiandrosterone eCG: Equine chorionic gonadotropin ER: Endoplasmic reticulum FHA: Functional hypothalamic amenorrhea FISH: Fluorescent in situ hybridization GABA: -amino butyric acid GnRH: Gonadotropin releasing hormone HPG: Hypothalamo-pituitary gonadal axis IFN: Interferon IVF: In vitro fertilization LC: L-carnitine LDL: Low density lipoprotein LH: Luteinizing hormone MII: Metaphase-II NO: Nitric oxide OCTN: Organic cation transporter OS: Oxidative stress PCOS: Polycystic ovarian syndrome PG: Prostaglandin PLC: Propionyl L-carnitine PMSG: Pregnant mares serum gonadotropin ROS: Reactive oxygen species SCC: Somatic cell count TNF: Tumor necrosis factor References Rutkowski M, Grzegorczyk K

If you do a lot of weight lifting with your arms, you lose fat throughout your body and build muscle in your arms
If GLP-1s do what the evidence suggests they will do, this will be one of the clearest demonstrations in modern psychiatry of why we fund preclinical research and why translational pipelines matter
Hypoglycaemia (low blood glucose) can occur, particularly when Ozempic is used in combination with insulin or sulfonylureas
After around four months of dose titration, most protocols aim for a semaglutide maintenance dose for weight loss of 2.4 mg per week