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One possible explanation for such a response is that inhibition of mTORC1 and activation of GCN2 collectively suppresses global translation to conserve nutrients, while selective translation of mRNA such as ATF4 (mediated by increased p-eIF2) activates the expression of AARE genes to mitigate cellular stress

doi: 10.1016/j.lfs.2022.121326 110

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However, emerging research suggests that collagenone of the most abundant proteins in our bodiesmay play a role in maintaining hair health and potentially slowing down the graying process

Normal cells are mostly unaffected because they do not depend on this FOXO4-p53 interaction for survival and are not already programmed to undergo cell death