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To contextualise that number: the landmark STEP 1 trial of semaglutide 2.4 mg showed a mean weight loss of approximately 14.9%, and the SURMOUNT-1 trial of tirzepatide reached 20.9% at its highest dose [2, 3]
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The largest decreases tend to require months
Both can be normal
Multiple miRNAs act on mast cells and are released by mast cells
For weight loss, FDA-approved options include orlistat, phentermine-topiramate, naltrexone-bupropion, liraglutide, semaglutide, and tirzepatide
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