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While semaglutide activates only the GLP-1 receptor, tirzepatide is a dual agonist that activates both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors

Author contributions JL and XL designed and outlined the work

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The Central Role of Enzymes as Biological Catalysts

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Despite this, people with type 2 diabetes tend to lose less weight on a GLP-1 than people who dont have the condition, and for reasons that arent quite clear, says Silvana Obici, MD, chief of the division of endocrinology at Stony Brook Medicine and medical director of the Stony Brook University Hospital Diabetes Center in New York