Mitochondrial dysfunction and the resulting oxidative stress in cochlear cells may arise from inherited mitochondrial DNA (mtDNA) mutations, which are associated with aminoglycoside-induced ototoxicity and hereditary hearing loss
These findings suggest that NHPN-1010 could be a beneficial agent for the treatment of NIT through reversal of cochlear synapthopathy in the IHC area and suppression of neuronal hyperactivity in the CAS
In models of retinal degeneration, Epitalon has been delivered via parabulbar injection, a technique that places the compound near the posterior eye to maximize local availability [64, 65]
Together with their antioxidant roles against reactive oxygen species (ROS) and reactive nitrogen species (RNS), NAC and HPN-07whose structural analog is -phenyl-N-tert-butylnitrone (PBN)have each been reported to promote neurogenesis through proposed mechanisms involving the activation of the Rasextracellular signal-regulated kinase (ERK) and protein kinase C (PKC) pathways 30,31,32
Long-term Metformin Use and Vitamin B12 Deficiency in the Diabetes Prevention Program Outcomes Study
Chen, W
