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Rapid weight loss reduces both the fat beneath your skin and the collagen and elastin that help keep it firm and plump, according to the Cleveland Clinic

NICE recommends considering this for people with a BMI 40 kg/m or 35 kg/m with comorbidities (with lower thresholds for people from certain ethnic groups), and for people with type 2 diabetes with a BMI between 30-34.9 kg/m

Supplementing with L-carnitine can raise blood levels of TMAO which can potentially advance atherosclerosis

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Long-term adherence is paramount for successful weight loss

Understanding their mechanism of action Lets explore how both medications work