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Dihexa is a small peptidomimetic that potentiates hepatocyte growth factor (HGF) signaling through the c-Met receptor at picomolar concentrations, demonstrating exceptional in vitro potency for promoting synaptogenesis

Activation of Spinal Glucagon-Like Peptide-1 Receptors Specifically Suppresses Pain Hypersensitivity

This gut-brain connection may modulate stress responses and attention allocation, though individual variation in receptor density and signaling efficiency likely determines clinical relevance for each person