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In Canada, GLP-1 medications are already a significant driver of drug plan spending an Alberta Blue Cross report that reviewed new drug and supplemental submissions made to Health Canada in 2025 named such treatments as a major cost of employer-sponsored drug plans, particularly as the drugs are approved for treatment of more conditions

This is one reason combination formulations have become popular in endocrinology research over the past decade

Fertility preservation: 250 to 500IU every other day throughout every suppressive cycle without interruption

The proportion of studies reporting effects varied substantially across regions ( Figure 2 , lower panel)