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Durability and Withdrawal Research SURMOUNT-4 showed that continuing Tirzepatide maintained and extended weight reduction, whereas withdrawal led to substantial regain in many participants
Other pharmacotherapy : Alternative anti-obesity medications such as orlistat may be considered, though evidence post-bariatric surgery is limited and NHS availability varies
12 weeks (avg 6 mg/week) 8 vials 72 mg total needed
Record lot information within institutional systems and follow established contamination control practices
One important context point the headline numbers miss: in STEP-1, while absolute lean mass dropped, lean body mass *as a proportion of total body mass* actually rose by roughly 3 percentage points