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While some users report feeling more sustained energy within the first two weeks, more noticeable changes in body composition and weight often appear after about 12 weeks of consistent use

10.1038/s41419-022-04517-1 103 WeghuberD.BarrettT.Barrientos-PrezM.GiesI.HesseD.JeppesenO

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In the Brain GLP-1 receptors in the hypothalamus (the region of the brain that controls hunger) are crucial for regulating appetite