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This treatment was associated with severe toxicities in several systems, but only hepatotoxicity was thought to be associated with the addition of retinoids

Treatment cycles typically last 4-8 weeks with 2-week breaks to prevent receptor desensitization

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Why the Myth Persisted The early concern came from animal studies showing ductal hyperplasia and from isolated reports of pancreatitis soon after drug initiation

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Only upon lysis of mitochondria by the addition of the detergent Triton X100 did the matrixlocalized probe became quickly reduced