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Multivalency, which allowed the engagement of multiple apo(a) K IV domains, considerably increased the potency and efficacy of inhibitors of Lp(a) formation in both in vitro and in vivo models of Lp(a) reduction, as compared with monovalency (Extended Data Table 6)

Support hepatic fat metabolism and methylation pathways rather than directly burning fat, which means results depend on concurrent dietary control and consistent dosing

In collaboration with Ezekiel Emanuel, MD, PhD from the University of Pennsylvania Perelman School of Medicine, Truveta Research explored the factors associated with discontinuation and subsequent reinitiation of GLP-1 RAs among adults with overweight or obesity

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Here are the key benefits of this unique combination: 1

In the 48-week trial, weight loss had not plateaued by the end of the study in the highest dose group