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An early publication in the Annals of the New York Academy of Sciences documenting the original discovery of telomere shortening as a primary mechanism of cellular senescence and its relevance to human aging biology provides the foundational framework for understanding why telomerase-activating compounds attract longevity research attention
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Clinical trials have used doses of 25-30 nmol/kg by IV infusion (Schneider-Helmert et al., 1981Subcutaneous administration and oral intestinal absorption have also been studied
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