In a widely cited New England Journal of Medicine trial using once-weekly semaglutide 2.4 mg plus lifestyle intervention in adults with overweight or obesity without diabetes, participants had a substantial and sustained reduction in body weight over 68 weeks
Novo and Hims had a partnership in 2025 allowing the telehealth company to offer injectable Wegovy, but the two companies walked away with Novo saying Hims had wrongfully marketed versions of its medicine
A 7-day gap between your last Mounjaro dose and your first Wegovy injection is usually enough to reduce overlapping side effects like nausea or bloating

When patients use both treatments concurrently, several precautions are warranted : Injection site management : Rotate sites systematically and avoid administering both injections in the same anatomical area on the same day Gastrointestinal monitoring : Tirzepatide's GI effects may be misattributed to lipotropic injections, potentially leading to inappropriate dose adjustments Hydration emphasis : Ensure adequate fluid intake given tirzepatide's potential to cause dehydration through GI effects Medication adjustments : Consider reducing doses of insulin or sulfonylureas when initiating tirzepatide to mitigate hypoglycemia risk Realistic expectations : Counsel patients that weight loss benefits derive primarily from tirzepatide's pharmacological action Cost considerations : Lipotropic injections represent additional out-of-pocket expense without proven incremental benefit Patients should seek immediate medical attention for severe or persistent abdominal pain (possible pancreatitis), right upper quadrant pain with fever or jaundice (gallbladder disease), signs of allergic reaction, persistent vomiting leading to dehydration, or symptomatic hypoglycemia if on insulin/sulfonylureas

The maximum dose is 3 mg per day, and the treatment duration depends on the individual's weight loss goals
Gastroenterology 141 , 21662175 e2167 (2011)