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CXCL8 is a protumorgenic chemokine, thus, this CXCL8-lowering effect of metformin was considered as a further indirect anticancer property of the drug
Then, the researchers administered exendin-4 via intrathecal injection to the experimental rats and observed a reduction in pain sensitivity, alleviation of neural inflammation, and suppression of inflammatory factors such as IL-1, TNF-, and iNOS
191196, Dec
PMID: 33996787
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