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Considered together, these features indicate that 2XSB cells will be a highly useful tool for deciphering the biology of sporadic MPNSTs and developing effective new treatments for these aggressive neoplasms

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Although plasma, serum and DBS represent distinct matrices collected and processed differently, we grouped them as blood-derived matrices due to the limited number of studies per matrix and the substantial variability in analytical methodologies and metabolite coverage across studies, consistent with the exploratory scope of this review

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