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The LEADER trial (liraglutide) reported pancreatitis in 0.3% of liraglutide patients versus 0.1% of placebo patients over a median 3.8 years

For women with PCOS or during menopause, GLP-1 may help support metabolic changes that are often hard to shift, but it isnt a standalone solution

Pinnen F, Cacciatore I, Cornacchia C, Sozio P, Iannitelli A, Costa M, et al

Despite the report that ARC GLP-1 signaling regulates glucose metabolism but not feeding behavior [61], it has also been shown that GLP-1R agonist liraglutide infusion in the ARC induces weight loss in rodents [33]

That said, compounded liraglutide*, an older GLP-1 medication, is still permitted and may be a viable option for some patients in cases when FDA-approved liraglutide products (like Saxenda and Victoza) are unavailable or unsuitable

In the SVZ, type B cellsadult multipotent NSPCs are located below ependymal and ependymal-like cells, which line the walls of the lateral ventricles (Mirzadeh et al., 2008)