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In conclusion, a growing body of evidence suggests that various natural products may exert beneficial effects on DOR by modulating PCD-related pathways

Insulin signaling pathway Insulin signaling in the brain is vital for the brain activity, and insulin resistance is one of key reasons of AD (213)

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In the context of SUD, such mechanisms could plausibly reduce craving and compulsive drug-seeking, aligning with preclinical work showing attenuation of substance-related reinforcement and with emerging clinical data suggesting reduced alcohol-related outcomes among GLP-1RA users (18, 35)

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