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The first phase revealed that peptide hormones can be subject to processing, and that their pro-forms may involve regulatory stages
Key evidence: A pilot RCT by Kumar et al
DES(1-3) IGF-1 is a truncated variant missing the first three N-terminal amino acids (Gly-Pro-Glu), which also reduces IGFBP binding but through a different structural mechanism removal of the N-terminal tripeptide rather than charge substitution
Glutathione, if used at all, is a supporting player, not the star
faster small-wound healing
Uncontrolled VEGF-A elevation has been associated with pathological angiogenesis, including tumor vascularization
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