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Cells release chemical messengers including interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and various prostaglandins

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Each was in the earlier stages of the disease, with symptoms ranging from mild to moderate

Due to the wide distribution of GLP-1R, GLP-1RAs also have a wide range of pharmacological effects

These findings held true even for patients with existing kidney impairment at baseline, suggesting GLP-1 therapy addresses a fundamental mechanism of renal disease rather than masking surface symptoms