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In fact, Urick believes the role of side effects and achieved weight loss goals have been underestimated in efforts to uncover the cause of GLP-1 discontinuation

Zhou X, Liu F, Zhai S

Wegovys ability to markedly impact blood sugar regulation and promote greater weight loss makes it a strong choice for those with Type 2 diabetes

Mechanistically, preclinical studies suggest that GLP-1RAs, including semaglutide, modulate the brain's reward and aversive systems

At each escalation point: Move to the next dose column on the chart

Phase 2 trial data (NEJM, 2023) showed substantial MRI-PDFF-measured liver fat reductions at 8 mg and 12 mg weekly doses, with some participants falling below the 5% hepatic steatosis threshold