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However, to make GLP-1 analogs work well required solving two key challenges a high enough dose and making the drug last longer in our bodies i.e

Semaglutide touches one of those pathways

This biocompatible approach makes weight management more consistent and manageable over time

Acknowledgments We thank the Mass Spectrometry & Metabolomics Core Facility, Laboratory Animal Resources Center and Center for Biomedical Research Core Facilities of Westlake University for sample analysis

We can use those

However, clinical use of GLP-1 has been limited by its short half-life, as a result of rapid degradation by dipeptidyl peptidase-IV (DPP-IV)