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Elimination of sitagliptin occurs primarily via renal excretion and involves active tubular secretion
Updated: Aug
doi: 10.1111/dom.12593 28 KanoskiSEHayesMRSkibickaKP
Given that reactive oxygen species (ROS) may trigger inflammation by promoting pro-inflammatory cytokines and activating the NF-B pathway, LCs antioxidant action indirectly reinforces its anti-inflammatory effects
The most likely explanation is that drugs, chronic disease, and chronic thiamine deficiency caused a dysfunction in not just total tissue TPP but also thiamine-dependent enzymes
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