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This is the same basic threshold used for GLP-1 weight loss medications

Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Boers GJH, den Heijer M, Kluijtmans LAJ, van den Heuvel LP, and Rozen R (1995)

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whether the same adverse event profile applies to subcutaneous administration of research chemicals at community-discussed doses is unknown

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This approach uses smaller amounts distributed across the week, which some patients find reduces nausea and side effects while still providing consistent appetite control