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The molecule was first identified and studied by the Sikiric research group in Croatia starting in the early 1990s, and the bulk of the preclinical evidence base comes from more than three decades of rat and rodent studies showing consistent tissue-repair, anti-inflammatory, and gastroprotective effects

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Week 7-8 (or 13-16): For persistent poor responders, consider final increase to 450-500mcg nightly, though additional benefit often minimal

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