Dipeptidyl peptidase 4 inhibition stimulates distal tubular natriuresis and increases in circulating sdf-1alpha(1-67) in patients with type 2 diabetes
Circulating NEFA concentrations are regulated by a balance between catabolic processes in adipose tissue and fatty acid substrate utilization by the skeletal muscle
Diabetologia 65(Suppl 1):S290S291 Gastaldelli A, Cusi K, Fernandez Lando L, Bray R, Brouwers B, Rodriguez A (2022) Effect of tirzepatide versus insulin degludec on liver fat content and abdominal adipose tissue in people with type 2 diabetes (SURPASS-3 MRI): a substudy of the randomised, open-label, parallel-group, phase 3 SURPASS-3 trial
Special population studies, including evaluation in elderly patients, patients with significant comorbidities, and patients with organ dysfunction, would help establish safety profiles for diverse clinical populations
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