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Disclosed by Eli Lilly investigators in 2022 under the development code LY3437943, retatrutide builds conceptually on the dual-incretin foundation established by tirzepatide while extending receptor engagement to include the glucagon receptor, a pharmacological pathway that earlier incretin research had largely avoided due to concerns about hyperglycemia and lipolysis

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[22] Peptides with pharmacological activity intended for human use including growth hormone secretagogues are likely to be classified as POMs by default if they were licensed, and their unlicensed supply for human use is therefore unlawful

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Lilly likewise states that retatrutide is not available for public use and remains legally available only through its clinical trials