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Among these defense networks, endogenous sulfhydryls, mainly reduced glutathione (GSH), have a major role in gastric mucosal cytoprotection against oxidative stress in a variety of models (Goldin et al, 1997
Under oxidative stress, this balance is disrupted-fusion is suppressed while fission is enhanced-resulting in mitochondrial fragmentation, cristae disorganization, and reduced efficiency of the electron transport chain (ETC)
Name, J
Iadecola, C
The neuroprotective role of estrogens implies a close regulation of processes such as (i) anti-oxidant activity (Kumar et al., 2010), (ii) DNA repair (Scharfman and MacLusky, 2006), (iv) synaptic plasticity (McEwen and Milner, 2007), and (v) the blood flow to the brain (Zhao and Brinton, 2006
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