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To calculate the sample size, we referred to previous studies [23], used the Stata software (sd1 = 2.65, sd2 = 3.53, power = 0.90, alpha = 0.0500 (two-sided), m 1 = 6.29, m 2 = 8.9, n 2 = 37/ n 1 = 37, n 1 = n 2 = 37)
Linagliptin belongs to a group called DPP-4 inhibitors, which are non-insulin medicines that help incretin hormones support insulin release after meals and reduce excess glucagon
Your healthcare provider should measure serum creatinine and estimated glomerular filtration rate (eGFR) before treatment initiation to establish a renal function baseline
The peptide can support remaining active follicles and potentially reactivate recently miniaturized ones
The researchers adjusted for age and BMI
Key Takeaways Metformin and GLP-1 agonists work synergistically to improve insulin response, reduce appetite, and support sustainable weight loss
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