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Water retention Some puffiness or bloating, especially in hands and face, as IGF-1 causes cells to hold more water

Always follow your healthcare providers guidance for safe and effective use

We keep moving the goalposts and it's exhausting." on her website ByAshleyFrench

Front Microbiol (2019) 10:2966

Since medication remains in your system for about five weeks after your last dose, side effects like nausea typically improve over 2 to 3 weeks as semaglutide levels decline

Support and reassurance from the NHS NICE TA875 and NHS Englands 2025 implementation framework both highlight that confidence in self-injection grows with experience and good guidance