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Some studies have evidenced that hyperinsulinemia may activate the renin-angiotensin system, increase sympathetic nervous system activity and renal sodium retention and, if sustained, all these elements could increase blood pressure (112, 114)
By activating both GIP and GLP-1 receptors, tirzepatide offers a potent combination of effects
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As noted above, subcutaneous WAT is viewed as metabolically healthy, while increased visceral WAT mass has been identified as a risk factor for cardiovascular disease, type 2 diabetes mellitus (T2DM), and steatohepatitis [72,73]
Mangiagalli MG, Cesari V, Cerolini S, Luzi F, Toschi L
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