Writingoriginal draft: JS
The bioavailability of glutathione tablets has improved significantly with advances in supplement technology
It irritates your stomach lining, leading to nausea and sometimes vomiting
In the retatrutide Phase 2 trial (Jastreboff et al., NEJM 2023), many participants found that symptoms such as diarrhoea, nausea, and abdominal discomfort improved after the initial weeks at a given dose, consistent with experience seen with licensed GLP-1 receptor agonists
Conversely, low-dose GLP-1 therapy is not appropriate for patients without established indications, particularly those seeking anti-inflammatory effects alone without diabetes or obesity
However, individuals have claimed their gastroparesis side effects did not resolve after stopping the medication, and have resulted in other permanent gastrointestinal injuries