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Moreover, a serious limitation with these datasets is the lack of sufficient patient level data to assess key variables, including other PDAC risk factors (particularly diabetes and obesity) as well as dosing and duration of drug exposure

This matters for two reasons

Manage Stress High stress levels can increase cortisol, leading to fat storage (especially around the belly)

This dual-action approach enhances insulin sensitivity and further reduces appetite and fat storage, often leading to even more substantial weight loss than GLP-1-only therapies

These issues highlighted the vulnerabilities of a market that had rapidly expanded around temporary shortage exemptions rather than long-term regulatory frameworks