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doi:10.1038/s42255-023-00916-6

Theoretical Concerns From Mechanism While NNMT inhibition is a promising research target, the mechanism raises points that warrant caution in interpretation

Overall, these findings collectively demonstrate that the molecular ruthenium catalyst Ru(II)-OH and the nanoparticle formulation NP2 are therapeutically active in a 21% O 2 atmosphere, but these lose their therapeutic efficiency in a 1% O 2 atmosphere