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With insulin, there is risk of weight gain, for hypoglycemia, and theres more treatment burden and need for glucose monitoring. GLP-1 drugs have also been shown to have cardiovascular benefits, she adds, though further clinical trials are needed to assess orforgliprons effects on heart health

Alimentary Pharmacol

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Nat Med 29 , 23582365 (2023)

The importance of insulin regulation and metabolic control has led to recruitment of genes in this pathway in venom function in various species

those on GLP-1s find that it helps with constipation in particular