56 These precedents led us to compare diastereomeric derivatives of GLP-1 and exendin-4 in which Gly10 or Gly4, respectively, was replaced by either ( S,S )-ACPC or ( R,R )-ACPC
Overall, dual and triple receptor agonists (like tirzepatide and retatrutide) appear to achieve superior weight loss outcomes compared to other GLP-1 RAs [82]
Both the / hydrolase and -propeller domains participate in inhibitor binding
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