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The titration schedule starts at 2 mg per week for 4 weeks, escalates to 4 mg for weeks 5 through 8, then to 8 mg for weeks 9 through 12, and reaches the 12 mg maintenance dose at week 13 (Jastreboff et al., NEJM 2023)

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They include various free radicals and reactive molecules formed from molecular oxygen and nitrogen, including superoxide anion radical (O ), hydroxyl radical (OH ), hydrogen peroxide (H 2 O 2 ), singlet oxygen ( 1 O 2 ), nitric oxide (NO), and peroxynitrite (ONOO ) [28]

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"It's not easy," the Grammy winner stressed