Research has linked prolonged PPI use to: Nutrient deficiencies (magnesium, calcium, iron, vitamin B12) (5) Increased risk of bone fractures and osteoporosis (6) Gut dysbiosis and increased risk of SIBO (7) Low stomach acid (which has been associated with leaky gut and autoimmune conditions) Higher susceptibility to infections Potential kidney and cardiovascular concerns (8, 9) Increased risk of cancer (10) Increased risk of inflammatory bowel disease (IBD) And, of course, PPIs do not address the root cause of reflux
By reducing your appetite, they make you eat less
Post-weight-loss hormonal adaptations exacerbate challenges, with decreases in anorexigenic hormones and increases in orexigenic ones driving weight regain (10)
Professor Tzu- Hao Wang, (M.D., Ph.D., Chang Gung hospital) is gratefully acknowledged for inspiration and initiation in multiomics of amniotic fluid
Bloating, Gas, and Reflux/Heartburn Shrink meal size , eat slowly, and avoid lying down for 23 hours after meals
Some compounding pharmacies even offer pre-mixed tirzepatide with glycine and B12 formulations
