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While SURPASS-CVOT showed that tirzepatide was noninferior to dulaglutide, uncertainty remains regarding how tirzepatide compares to the broader GLP-1RA class and other GLP-1RA agents, and the extent to which it provides incremental benefit over placebo

You can use the Bristol Stool Chart to identify if you are experiencing constipation: Type 1: Separate, hard, nut-like lumps that are hard to pass

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Use caution in affected patients

It may also help reduce symptoms such as muscle cramps, fatigue, and headaches