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Editorial: new drug targets for proteotoxicity in cardiometabolic diseases

404,405 In particular, reduced renal excretion leads to abnormal plasma adipokines levels including leptin and adiponectin in CKD patients

Frederick Sanger (1918-2013) sequenced bovine insulin in 1955, identifying its exact amino-acids composition, 2,3 and was awarded with the Nobel Prize for Chemistry in 1958

TLR1, TLR2 and TLR4 activation results in augmented mitochondrial ROS production following recruitment of mitochondria to macrophage phagosomes, leading the way to increased mitochondrial and cellular ROS generation (West et al., 2011)

A lack of B vitamins, found in green vegetables and a healthy gut, can change the MTHFR enzyme gene, disrupting important body processes

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