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Patients could start with injectable tirzepatide for aggressive weight loss, then transition to oral orforglipron for convenient long-term maintenance

Drowsiness and Fatigue : Topiramate can make you feel very tired or sleepy

Probiotics, by contrast, would theoretically work by modestly influencing the body's own GLP-1 productiona far less direct and potentially much weaker effect

In these cases, the body may not absorb enough B12 from food or even from oral supplements

Hogan K, Lyttle Z, Schonfeld A

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