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Trials to fit a horseshoe shaped molecule, as has been observed both in LTC4S (PDB ID: 2UUH and 2PNO) and MPGES1 (PDB ID: 3DWW and 4AL0), were not successful and led to reduction of refinement statistical criteria

The fine-tuning of TRAF2-GSTP1-1 interaction: effect of ligand binding and in situ detection of the complex

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Under conditions of hypoxia, the low levels of oxygen lead to accumulation of NADH and under these conditions mitochondria can increase the oxidation of NADH via the LDH-mediated reduction of pyruvate

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While shifts in carbohydrate, amino acid and lipid metabolism indicate altered substrate utilization under nutrient-limited conditions, direct impacts on cellular energy status cannot be inferred, as changes in adenylic nucleotides, phosphagens, and cellular energy charge were not detected in this study