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The MetroHealth System, Cleveland OH, IRB determined research using TriNetX as described in this study was not Human Subject Research, and IRB approval is not required (more details in the Supplementary Appendix)

New England Journal of Medicine ): STEP UP Clinical Trial / FDA Approval (March 2026): Evaluated the safety and efficacy of the newly approved once-weekly semaglutide 7.2 mg (Wegovy HD) for chronic weight management

Insulin , a hormone produced by the pancreas, helps transport glucose into cells

This is higher than standard recommendations (0.8g/kg) because protein needs significantly increase during caloric restriction to prevent muscle breakdown and support muscle protein synthesis

Ferrous sulfate (fe2+) had a faster effect than did ferric polymaltose (fe3+) on increased oxidant status in children with iron-deficiency anemia

Phentermine is typically prescribed for short-term use due to its stimulant properties