glp-1 and heartburn is a side effect of glp 1 Acid Reflux & Semaglutide Experiencing heartburn while on GLP-1s? – GLP-1 Agonists in Cardiovascular Diseases:

You and your doctor make that call together, visit by visit

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Serious risks are less common but include pancreatitis and, based on animal studies, a theoretical risk of thyroid C-cell tumors, which is why GLP-1 medications are contraindicated in patients with a personal or family history of medullary thyroid carcinoma